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Monoclonal Anti-AP2 antibody produced in mouse

品牌
Sigma-Aldrich
货号
A7107
规格纯度
~1.0 mg/mL, clone A6/2/2, purified immunoglobulin, buffered aqueous solution
价格
5236.52 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-AP2 antibody produced in mouse
Anti-AP2TF
Anti-TFAP2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Adaptor protein-2 (AP2) is a key constituent of clathrin-coated vesicles that mediates the endocytosis of cell membrane components such as G protein-coupled receptors (GPCRs). AP2 is a heterotetramer that consists of α, β, μ and σ subunits which bind to tyrosine- and dileucine-based motifs on membrane-associated cargo proteins.
Monoclonal Anti-AP2 (mouse IgG1 isotype) is derived from the hybridoma A6/2/2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to amino acids of human AP2α. In humans and mice, the adaptor protein-2 (AP2) family comprises five different transcription factors namely AP2α, AP2β, AP2 γ, AP2δ, and AP2ε. These proteins contain N-terminal transactivation domain and C-terminal helix-span-helix motif, which together with a central basic region facilitates dimerization and DNA binding.

免疫原

peptide corresponding to amino acid 415-433 of human AP2α.

应用

Monoclonal Anti-AP2 antibody produced in mouse has been used in:

  • immunofluorescence staining
  • immunoblotting
  • immunohistochemistry

生化/生理作用

Adaptor protein-2 (AP2) expression is associated with the embryonic development. AP2β was found to be a tumor specific human telomerase reverse transcriptase (hTERT) promoter activator, suggesting it may be a biomarker for cancer diagnosis or as a cancer therapeutic target for inhibiting hTERT activity and tumor cell growth. In humans, mutations or loss of these genes result in increased tumor growth and metastasis. Specifically, AP2α loss causes down regulation of E-cadherin and matrix metallopeptidase 9 (MMP-9) activity, which in turn enhance tumorigenicity of colon cancer cells. This effect may also be the result of AP2α regulation by p53.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 A6/2/2, monoclonal
形式 buffered aqueous solution
分子量 antigen ~50 kDa
species reactivity human
浓度 ~1.0 mg/mL
technique(s) immunohistochemistry: suitable
western blot: 2-4 μg/mL using G361 total cell extract
同位素/亚型 IgG1
UniProt登记号 P05549
运输 dry ice
储存温度 ?20℃
Gene Information human ... TFAP2A(7020)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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