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Anti-ATM antibody,Mouse monoclonal

品牌
Sigma-Aldrich
货号
A1106
规格纯度
clone MAT3-4G10/8, purified from hybridoma cell culture
价格
1303.85 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-ATM antibody,Mouse monoclonal
Anti-Ataxia-Telangiectasia Mutated
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-ATM (mouse IgG1 isotype) is derived from the hybridoma MAT3-4G10/8 produced by the fusion of mouse myeloma cells (NSO) and splenocytes from BALB/c mice immunized with a peptide.

特异性

Monoclonal Anti-ATM antibody reacts specifically with mouse and human ATM.

免疫原

peptide spanning positions 1967-1988 of mouse ATM containing a cysteine at its NH2 terminus coupled to KLH.

应用

Monoclonal Anti-ATM antibody can be used in immunoblotting , ELISA and immunoprecipitation.

生化/生理作用

Anti-Ataxia-Telangiectasia Mutated (ATM) is responsible for the activation and stabilization of p53 in response to double-strand break (DSB). ATM phosphorylates p53 directly on Ser15 and concomitantly activates other kinases that phosphorylate the same molecule on additional sites. Furthermore, human homolog of double minute 2 (Hdm2) is phosphorylated by ATM on Ser395 and this phosphorylation inhibits Hdm2-mediated degradation of p53.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01321740

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
重组 expressed in mouse cell line
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 MAT3-4G10/8, monoclonal
形式 PBS solution
分子量 antigen ~300 kDa
species reactivity mouse, human
包装 antibody small pack of 25 μL
浓度 ~2 mg/mL
technique(s) immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract
同位素/亚型 IgG1
UniProt登记号 Q13315
运输 dry ice
储存温度 ?20℃
Gene Information human ... ATM(472)
mouse ... Atm(11920)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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