半岛bd体育手机客户端 说明
一般描述
Adrenergic receptors (ARs) belong to the 7-transmembrane domain G protein-coupled receptor superfamily that binds to the endogenous catecholamines, epinephrine and norepinephrine. α2AR subtypes block adenylyl cyclase, suppress voltage-sensitive Ca2+channels, and stimulate receptor dependent K+channels. All of the α2AR subtypes inhibit adenylyl cyclase through coupling to members of the Gi/Goclass of G proteins. They are an important component of the neural circuitry and modulate cardiovascular physiology. The physiological function of the α2ARs in the kidney is to regulate Na+/H+exchange.
Anti-α2Aadrenergic receptor detects rat and mouse α2Aadrenergic receptors by immunoblotting and immunohistochemistry. In immunoblotting, the antibody detects an approx. 45kDa band representing α2Areceptors in tissues expressing this receptor subtype, although some non-specific bands have also been observed in certain cases.
免疫原
synthetic peptide derived from amino acids 218-235 of human, mouse, rat, and pig α2Aadrenergic receptor. The immunogen sequence is found within the third intracellular loop of the α2Aadrenergic receptor subtype.
应用
Rabbit anti-α2Aadrenergic receptor antibody can be used for western blot (1:500) and immunohistochemistry (1:1000) applications.
外形
Solution in phosphate buffered saline, containing 1 mg/ml BSA and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD01321639 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~45 kDa |
| species reactivity | rat, pig, human, mouse |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000 western blot: 1:500 |
| UniProt登记号 | P08913 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... ADRA2A(150) mouse ... Adra2a(11551) rat ... Adra2a(25083) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
