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Anti-Wnt3a Antibody

品牌
Sigma-Aldrich
货号
09-162
规格纯度
Upstate?, from rabbit
价格
6694.05 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Wnt3a Antibody
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The Wnt family of consists of ligands involved in cell development, fate determination, organogenesis, and oncogenesis. Information on Wnt signaling has been inferred from genetic analysis of wingless (wg) signaling in Drosophila. The Wnt signaling cascade initiates at the cell membrane when Wnt interacts with its receptor, a member of the Frizzled (Fz) transmembrane receptor family and lipoprotein receptor–related proteins 5 and 6 (LRP-5/6). This interaction relays the signal into the interior of the cell where disheveled (dsh) is brought to the membrane and gets phosphorylated/activated. Dsh promotes the inactivation of GSK3 kinase activity, thus preventing the phosphorylation of β-Catenin and allowing it to accumulate as it avoids ubiquination and subsequent proteosome degradation. Stable β-Catenin accumulates in the cytoplasm where it interacts with lymphoid enhancer factor/T cell factor (LEF/TCF) and translocates into the nucleus. This results in activation of TCF-responsive genes which are thought to play key roles in development and cancer. Negative regulators of the pathway may include axin and the tumor suppressor APC.

特异性

Recognizes Wnt3A

免疫原

Synthetic KLH-conjugated peptide directed against the central region of human, mouse, and rat Wnt3A.
Epitope: Central

应用

Anti-Wnt3A Antibody is an antibody against Wnt3A for use in WB, IH(P).
Research Category
Signaling
Research Sub Category
Developmental Signaling

质量

routinely evaluated by immunoblot on rat brain lysate

目标描述

~40 kDa

外形

Affinity purified
Affinity purified rabbit polyclonal in storage buffer containing PBS and 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity rat, human, mouse
manufacturer/tradename Upstate?
technique(s) immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型 IgG
NCBI登记号 NP_149122
UniProt登记号 P56704
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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