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位置: 首页> 品牌> Sigma-Aldrich> Anti-PI3 Kinase Antibody, p110β

Anti-PI3 Kinase Antibody, p110β

品牌
Sigma-Aldrich
货号
09-482
规格纯度
from rabbit, purified by affinity chromatography
价格
5016.79 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-PI3 Kinase Antibody, p110β
PI3-kinase p110 subunit alpha, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha, PtdIns-3-kinase p110, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform, ph
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival, signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.

特异性

Recognizes the internal domain of PI3 Kinase, p110β.

免疫原

KLH-conjugated synthetic linear peptide corresponding to the internal domain of PI3 Kinase, p110β.
Epitope: Internal Domain

应用

Anti-PI3 Kinase Antibody, p110β is an antibody against PI3 Kinase for use in WB, IP, IC, IH, ELISA.
ELISA:
This antibody was tested and determined to work for ELISA at 0.5 ng/well.

Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

质量

Evaluated by Western Blot on HEK-293 cell lysate.
Western Blot Analysis: 0.05 - 0.1 μg/mL of this antibody detected endogenous PI3 Kinase, p110β in lysate from HEK-293 cells.

目标描述

110 kDa

联系

Replaces: 04-399

外形

Antigen affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4), 150mM NaCl, with 0.05% NaN3.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8?C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

分析说明

Control
HEK-293 cell lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity canine, human
species reactivity (predicted by homology) monkey (immunogen homology), mouse (immunogen homology), dog (immunogen homology), rat (immunogen homology)
technique(s) ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号 NP_006210.1
UniProt登记号 P42336
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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