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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-PAK1 (Ser199/Ser204) Antibody

Anti-phospho-PAK1 (Ser199/Ser204) Antibody

品牌
Sigma-Aldrich
货号
09-258
规格纯度
Upstate?, from rabbit
价格
5854.74 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-PAK1 (Ser199/Ser204) Antibody
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

p21-activated kinases (PAK) are Ser/Thr kinases, which are activated by, and are effectors of Rho family of GTPases. As such, they are implicated in Actin polymerization and activation of the stress-activated kinase cascades. PAK1 is phosphorylated by cdk5, resulting in its inhibition. PAK2 can be activated by Caspase-cleavage in addition to p21-binding, implicating it in cytoskeletal changes during apoptosis. PAK3 is expressed at high levels in post-mitotic neurons of the developing post-natal cerebral cortex and hippocampus, and is the mutant gene thought responsible for non-syndromic X-linked mental retardation.

特异性

Recognizes PAK1 phosphorylated on Ser199 and Ser204 (human)/Ser198 and Ser203 (mouse). Immunogen sequence is higly homolgous (greater than 90%) with PAK2 and PAK3.

免疫原

Epitope: Ser199/Ser204 (Central)
Amino Acids encompassing and including phosphorylated Ser199 and Ser204 of human PAK1. Sequence is highly homologous (greater than 90%) to PAK2 and PAK3.

应用

Research Sub Category
Cytoskeletal Signaling
Detect phospho-PAK1 (Ser199/Ser204) using this Anti-phospho-PAK1 (Ser199/Ser204) Antibody validated for use in WB.
Research Category
Signaling

质量

Routinely evaluated by western blot on untreated and pervanadate-treated Jurkat cell lysates.

目标描述

65 kDa

外形

Double affinity purification over both non-phospho-peptide column followed by phopshorylated peptide column.
Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol

储存及稳定性

Stable for 1 year at -20°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
species reactivity (predicted by homology) mouse (100% immunogen homology), rat (100% immunogen homology)
manufacturer/tradename Upstate?
technique(s) western blot: suitable
NCBI登记号 NP_002567
UniProt登记号 Q13153
运输 dry ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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