Anti-phospho-JAK2 (Tyr1007/1008) Antibody

半岛bd体育手机客户端 说明

一般描述

Janus kinase 2 (JAK2) is a ubiquitous non-receptor tyrosine kinase that interacts with multiple cell-surface receptors and non-receptor proteins to affect a range of cellular processes including immunity, cell growth, development, and differentiation. Among JAK2’s receptor partners are the prolactin, growth hormone, thrombopoitin, and INF (α and β) receptors. JAK2 plays an important role in connecting the signaling pathways of these receptors to the activation of target genes. Upon ligand binding these receptors activate JAK2 inducing JAK2 autophosphorylation; This activated JAK2 in turn phosphorylates the cytoplasmic domains of these receptors providing a binding site for STAT transcription factors which are also phosphorylated by JAK2 leading to STAT protein dimerization and translocation to the nucleus to effect gene transcription. Aberrations in JAK2 expression and function may contribute to myelofibrosis and myelogenous leukemia.

特异性

This antibody recognizes JAK2 phosphorylated at (Tyr1007/Tyr1008).

免疫原

KLH-conjugated linear peptide corresponding to human JAK2 phosphorylated at (Tyr1007/Tyr1008).
Epitope: Phosphorylated (Tyr1007/Tyr1008)

应用

Research Category
Signaling
Anti-phospho-JAK2 (Tyr1007/1008) Antibody is an antibody against phospho-JAK2 (Tyr1007/1008) for use in WB.

质量

Evaluated by Western Blot in LPS/IFN gamma untreated and treated RAW264.7 cell lysates.

Western Blot Analysis: A 1:5,000 dilution of this antibody detected JAK2 on 10 ?g of LPS/IFN gamma untreated and treated RAW264.7 cell lysates.

目标描述

~130 kDa observed. Uncharacterized bands appear at ~48, 55, 65, and 100 kDa in some lysates.

联系

Replaces: 04-1098

外形

Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
LPS/IFN gamma untreated and treated RAW264.7 cell lysates

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	mouse, pig
species reactivity (predicted by homology)	rat (based on 100% sequence homology), zebrafish (based on 100% sequence homology),Xenopus(based on 100% sequence homology), porcine (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology)
technique(s)	western blot: suitable
NCBI登记号	NP_004963
UniProt登记号	O60674
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable