半岛bd体育手机客户端 说明
一般描述
Dock2 (Dedicator of cytokinesis 2), is a large protein involved in intracellular signaling networks and a member of the DOCK-A subfamily which function as activators of small G proteins. Dock2 specifically activates isoforms of the small G protein Rac and appears to be expressed specifically in leukocytes. These cells express both Rac1 and Rac2 and Dock2 has been shown to bind and promote nucleotide exchange on both of these isoforms. (Nishihara, 1999)
特异性
09-454 recognizes mouse DOCK2.
Predicted to cross react with human, equine, and primate, based on 93% sequence homology (13/14 aa). The sequence is 85.7% homologous in rat. Reactivity with other species has not been tested.
免疫原
Epitope: Internal region
KLH-conjugated synthetic peptide near amino acid 1730, within the internal region of mouse DOCK2.
应用
Research Category
Cell Structure
Western Blotting; Anti-Dock2 Antibody is an antibody against Dock2 for use in WB
Immunohistchemistry (Frozen sections): A representative lot of this antibody dectected DOCK2 in mouse and human brain frozen tissue sections (Cimino, PJ et al. (2009). Am. J. Pathol. 175(4); 1622-1630)
Research Sub Category
Cytoskeleton
质量
Evaluated by Western blot on mouse spleen lysate 0.5 μg/mL of Anti-DOCK2 at 1 mg/mL.
目标描述
180 kDa
外形
Purified in PBS containing 0.05% NaN3.
Peptide affinity purified
储存及稳定性
Maintain at 2-8°C for up to 1 year from date of receipt.
分析说明
Control
Mouse spleen lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | primate, mouse, horse, human |
technique(s) | immunohistochemistry: suitable western blot: suitable |
同位素/亚型 | IgG |
NCBI登记号 | NM_004946.2 |
UniProt登记号 | Q8C3J5 |
运输 | wet ice |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich