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位置: 首页> 品牌> Sigma-Aldrich> Fmoc-Sec(pMeOBzl)-OH

Fmoc-Sec(pMeOBzl)-OH

品牌
Sigma-Aldrich
CAS
150308-80-8
货号
8.52346
规格纯度
Novabiochem?
价格
3937.68 *本价格含增值税费
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半岛bd体育手机客户端 名称:
150308-80-8
Fmoc-Sec(pMeOBzl)-OH
Fmoc-Sec(Mob)-OH,Fmoc-S-4-methoxybenzyl selenocysteine
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Building block for the introduction of selenocysteine during Fmoc SPPS [1-3]. Selenocysteine derivatives can undergo enantiomerization during coupling and can form dehydroalanine and β-piperidinylalanine containing side products during subsequent chain elongation [3]. Therefore, activation methods, such as HBTU or PyBOP which involve the addition of a tertiary, base should be avoided for addtion of the Sec and all subsequent residues.



Cleavage and side-chain deprotection of Sec-containing peptides can be effected using tFA-m-cresol-thioanisole-EDT-water (80:5:5:5:5)[2] or TFA-water-DCM-TIS (89:5:51) at 4 °C [3]. As the Se-pMeOBzl bond is stable to TFA, these emthods result in formation of the corresponding Sev(pMeOBzl) peptide.



Peptides containing two Sec(pMeOBzl) residues can be oxidized directly to the corresponding selenocystinyl peptides by treatment with 5-10% DMSO in TFA [1-3].

分析说明

Color (visual): white to yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(157A)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1?mmole in 2 ml DMF): clearly soluble
For TLC-Systems see our General Catalog

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C26H25NO5Se
分子量 510.44

半岛bd体育手机客户端 性质

质量水平 200
半岛bd体育手机客户端 线 Novabiochem?
测定 ≥98% (TLC)
≥98.0% (HPLC)
形式 powder
reaction suitability reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename Novabiochem?
官能团 Fmoc
储存温度 2-8℃

安全信息

象形图 GHS06GHS08GHS09
警示用语: Danger
危险声明 H301 + H331 - H315 - H335 - H373 - H410
预防措施声明 P260 - P273 - P301 + P310 - P302 + P352 - P304 + P340 + P311 - P314
危险分类 Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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