半岛bd体育手机客户端 说明

一般描述

Rink acid resin is a super acid-labile support for the solid phase immobilization of carboxylic acids [1]. Cleavage can be effected with as little as 10% AcOH in DCM, providing highly acid-sensitive products in high yields and purities. However, care must be taken to prevent product loss during synthetic manipulations [2], owing to the extreme acid sensitivity of this support.

Treatment with HCl in THF [3] or Ph₃PCl₂[4] has been shown to efficiently convert this resin to the corresponding benzhydryl chloride, to which can be coupled a wide range of functional groups: hydroxylamines [3], alcohols, amines, acids and thiols [4].

Rink acid resin has also been converted to a trifluoroacetate with TFA and used in a similar manner to immobilize amines, thiols, alcohols, and phenols [5]. In a more detailed study, the same authors found 1 M trifluoroacetic anhydride in 2,6-lutidine to give superior results with less degradation of the linker [6, 7]. Rink resin trifluoroacetate has also been used to prepare purines [8, 9].

Cleavage of amines and alcohols from this support has been carried out with either 5% TFA in DCM [4] or 20% TFA in DCM [5]; thiols were released with either 5% TFA in DCM [4] or 95% aq. TFA [5].



The product number for this product was previously 01-64-0012.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

联系

Replaces: 01-64-0012

分析说明

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substition of the Fmoc-NH2 loaded resin): 0.35 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

半岛bd体育手机客户端 性质

质量水平	200
半岛bd体育手机客户端 线	Novabiochem?
形式	beads
reaction suitability	reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename	Novabiochem?
官能团	alcohol
储存温度	2-30℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable