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位置: 首页> 品牌> Sigma-Aldrich> Anti-Partitioning-defective 3 Antibody, Alexa Fluor?488 Conjugate
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Anti-Partitioning-defective 3 Antibody, Alexa Fluor?488 Conjugate

品牌
Sigma-Aldrich
货号
07-330-AF488
规格纯度
from rabbit, ALEXA FLUOR?488
价格
6861.94 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Partitioning-defective 3 Antibody, Alexa Fluor ?488 Conjugate
Partitioning defective 3 homolog, PAR-3, PARD-3, Atypical PKC isotype-specific-interacting protein, ASIP, CTCL tumor antigen se2-5, PAR3-alpha, Partitioning-defective 3, Alexa Fluor 488 Conjugate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Partitioning defective 3 homolog (UniProt Q8TEW0; also known as ASIP, Atypical PKC isotype-specific-interacting protein, Bazooka, CTCL tumor antigen se2-5, Par-3 family cell polarity regulator alpha, Par-3 partitioning defective 3 homolog, PAR3-alpha, Protein phosphatase 1 regulatory subunit 118) is encoded by the PARD3 (also known as Baz, PAR3, PAR3A, PARD3A, PPP1R118) gene (Gene ID 56288) in human. Par3 is a PDZ (PSD95/Dlg/ZO-1) domain-containing membrane scaffold adapter protein that plays an important role in epithelial cell tight junction (TJ) formation and apico-basal polarity maintenance. Together with PAR6, atypical protein kinase C (aPKC), and the Rho GTPase CDC42, Par3 forms a complex that regulates cytoskeleton re-organization, post-golgi vesicle trafficking, microtubule network polarization, and asymmetric cell division. PAR6 interacts directly with aPKC isoforms iota/lambda and zeta to form the complex core. Recruitment of GTP-bound CDC42 to the PAR6-aPKC core induces aPKC phosphorylation/activation by PAR6, and subsequent PAR3 binding. Another quaternary apical junctional complex (AJC), Willin–Par6-aPKC–Par3, has also been reported. In this case, the complex-associated aPKC functions to phosphorylate ROCK, resulting in ROCK dissociation from the AJC and thereby preventing excessive ROCK-dependent apical constriction.

特异性

Expected to react with all 11 spliced isofoms (UniProt Q8TEW0-1 to Q8TEW0-11).

免疫原

GST fusion protein corresponding to residues 457-744 of mouse PAR-3 (accession number AY02657).

应用

Research Category
Cell Structure
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Partitioning-defective 3 in A431, and NIH/3T3 cells.
The unconjugated antibody (Cat. No. 07-330) is shown to be suitable also for Western blotting, immunocytochemistry, and immunohistochemistry applications.
This Anti-Partitioning-defective 3 Antibody, Alexa Fluor?488 Conjugate is validated for use in Immunocytochemistry for the detection of Partitioning-defective 3.
Research Sub Category
Adhesion (CAMs)

质量

Evaluated by Immunocytochemistry in HUVECs.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Partitioning-defective 3 in HUVECs.

目标描述

~180, 150, 100 kDa observed

外形

Purified rabbit conjugate antibody in PBS with 15 mg/ml BSA and 0.1% sodium azide.
Protein A purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

法律信息

ALEXA FLUOR is a registered trademark of Life Technologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 ALEXA FLUOR?488
抗体形式 purified antibody
antibody product type primary antibodies
克隆 polyclonal
species reactivity mouse, rat, monkey, frog, canine, human
technique(s) immunocytochemistry: suitable
NCBI登记号 NP_062565
UniProt登记号 Q8TEW0
运输 wet ice
Gene Information human ... PARD3(56288)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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