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位置: 首页> 品牌> Sigma-Aldrich> PP2A phosphatase activator, PP2A, subunit B′, PP2A, subunit B′, PR53 isoform, Phosphotyrosyl phosphatase activator, protein phosphatase 2A activator, regulatory subunit 4, protein phosphatase 2A, regulatory subunit B′, protein phosphatase 2A, regulatory

Anti-PP2A-B′ (B56) Antibody

PP2A phosphatase activator, PP2A, subunit B′, PP2A, subunit B′, PR53 isoform, Phosphotyrosyl phosphatase activator, protein phosphatase 2A activator, regulatory subunit 4, protein phosphatase 2A, regulatory subunit B′, protein phosphatase 2A, regulatory

品牌
Sigma-Aldrich
货号
07-1221
包装型号
规格纯度
from rabbit
价格
5211.96 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-PP2A-B′ (B56) Antibody
PP2A phosphatase activator, PP2A, subunit B′, PP2A, subunit B′, PR53 isoform, Phosphotyrosyl phosphatase activator, protein phosphatase 2A activator, regulatory subunit 4, protein phosphatase 2A, regulatory subunit B′, protein phosphatase 2A, regulatory
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PP2A is a heterotrimeric type 2 Ser/Thr phosphatase, composed of a structural subunit (A), a regulatory subunit (B), and a catalytic subunit (C). The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. There are multiple isotypes (encoded by distinct genes) of the B subunit, grouped into three families: B/PR55, B′/PR61, and B′′/PR72 . The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B′ (or B56) family consists of at least seven splice variants derived from five genes. RNA′s for the two members of the B′′ family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B′ subunits are conserved from yeast to mammals. PTPA is a member of the B′ family that is required for activation of PP2A by an undefined mechanism. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid. It is also thought to be the principal downmodulator of Ser/Thr kinase cascades.

特异性

This antibody is specific to PP2A-B’ subunits.

免疫原

Epitope: Internal
The immunogen used for the purified peptide conjugated to KLH corresponds to the sequence NH2-Val-Ser-Ser-Pro-His-Phe-Gln-Val-Ala-Glu- Arg-Ala-Leu-Tyr-COOH.

应用

Research Sub Category
PI3K, Akt, & mTOR Signaling

Kinases & Phosphatases
Research Category
Signaling
Detect PP2A-B’ (B56) using this Anti-PP2A-B’ (B56) Antibody validated for use in WB.

质量

Routinely evaluated by Western Blot on HeLa lysates.

Western Blot Analysis: 1:500-1:1,500 dilution of this antibody detected PP2A-B′ (B56) in 10 μg of multiple cell lysates.

目标描述

~56 kDa

联系

Replaces: AB4088

外形

Purified
Format: Purified
Purified rabbit polyclonal IgG in PBS with 0.08% sodium azide.

储存及稳定性

Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
HeLa Cell Lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 polyclonal
species reactivity rat, human, mouse, bovine
technique(s) western blot: suitable
同位素/亚型 IgG
NCBI登记号 NM_006243
UniProt登记号 Q15257
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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