Anti-phospho-PLK1 (Ser137) Antibody

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一般描述

Polo-like Kinase 1 (PLK1) is a serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Expressed PLK protein accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.

特异性

This antibody recognizes phosphorylated PLK1 at Ser137.

免疫原

KLH-conjugated linear peptide corresponding to human phosphoylated PLK1 at and around Ser137.

应用

Western Blot (SNAP ID) Analysis: 0.5 ?g/mL of this antibody detected PLK1 phosphorylated at Ser137 in human placenta tissue lysate.
Detect phospho-PLK1 (Ser137) using this Anti-phospho-PLK1 (Ser137) Antibody validated for use in WB.
Research Category
Signaling
Research Sub Category
Kinases & Phosphatases

质量

Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 0.5 ?g/mL of this antibody detected PLK1 phosphorylated at Ser137 in lambda phosphatase treated and untreated human placenta tissue lysate.

目标描述

68 kDa

外形

Affinity purified
Affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4), 150mM NaCl with 0.05% sodium azide.

储存及稳定性

Maintain refrigerated at 2-8°C for up to 12 months.

分析说明

Control
Lambda phosphatase treated and untreated human placenta tissue lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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