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Anti-EZH2 Antibody

品牌
Sigma-Aldrich
货号
07-1562
规格纯度
serum, Upstate?
价格
6694.05 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-EZH2 Antibody
SETDB1, EC 2.1.1.43

SET domain bifurcated 1

ERG-associated protein with SET domain

ESET

Histone H3-K9 methyltransferase 4

H3-K9-HMTase 4

Lysine N-methyltransferase 1E
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Polycomb protein group complexes are responsible for the regulation of hundreds of genes in mammals and insects. These proteins are responsible for the assembly and packaging of chromatin and for the induction of methylation on Histone H3. EZH2 (enhancer of zeste homologue 2), also known as Enx1, is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. The expression of this protein in human tumors is aggressive for hormone refractory prostate cancer. In breast cancer EZH2 expression was increased in malignant tumors and promoted anchorage independent and invasive growth in vitro.. EZH2, also known as ENX-1, is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, EZH2 is restricted to the spleen, testis and placenta. EZH2 and BMI-1 genes are co expressed in Reed-Sternberg cells of Hodgkin’s disease. Coexpression of BMI-1 and EZH2 is also associated with cycling cells and degree of malignancy in B-cell non-Hogkin’s lymphoma. EZH2 is involved in the progression of prostate cancer, and has been identified as a marker of aggressive breast cancer. Two transcript variants encoding distinct isoforms have been identified for this gene.

特异性

Recognizes EZH2, Mr ~100 kDa

免疫原

KLH-conjugated, His-tagged fusion protein corresponding to residues 406-746 of human EHZ2 (similar to enhancer of zeste (Drosophila) homolog 2). Based on accession # BC010858.

应用

Use Anti-EZH2 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EZH2 also known as SET domain bifurcated 1, ERG-associated protein with SET domain.
Research Sub Category
Chromatin Biology

Histones
Research Category
Epigenetics & Nuclear Function

质量

Routinely evaluated by immunoblot analysis

目标描述

95-100kDa

联系

Replaces: 04-1047

外形

Serum

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
A431 cell lysate

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 serum
antibody product type primary antibodies
克隆 polyclonal
species reactivity rat, mouse, human
manufacturer/tradename Upstate?
technique(s) western blot: suitable
GenBank?accession no. BC010858
NCBI登记号 NM_004456.3
NM_152998.1
UniProt登记号 Q15910
运输 wet ice
Gene Information human ... EZH2(2146)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2

Sigma-Aldrich

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