Anti-CENP-A Antibody

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一般描述

CENP-A is a variant version of histone H3 found only at centromeres.
Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.

特异性

CENP-A
Broad species cross-reactivity is predicted.

免疫原

peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A

应用

Anti-CENP-A Antibody is a Rabbit Polyclonal Antibody for detection of CENP-A also known as Centromere autoantigen A & has been tested in WB.
Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Epigenetics & Nuclear Function

质量

routinely evaluated by immunoblot in acid extracted histones from HeLa cells

目标描述

17kDa

联系

Replaces: 04-205

外形

Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.
ImmunoAffinity Purified

储存及稳定性

Stable for 1 year at 2 to 8ºC from date of receipt.

分析说明

Control
Control Histones (from Hela cells) colcemid-treated or untreated

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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