半岛bd体育手机客户端 说明
一般描述
Chromobox protein homologue 7 (Cbx7) is a member of the mammalian chromobox family of proteins. As a component of the Polycomb repressive complex 1 (PRC1), Cbx7, is involved in the maintenance and prolongation of cultured epithelial cell lifespan, and has been shown to function independently of BMI-1 in the repression of INK4a/ARF, a known tumor suppressor locus. Cbx7 is also able to regulate cellular lifespan through maintaining CDKN2A repression. Studies have shown Cbx7 to be up-regulated in follicular lymphoma, suggesting potential as a human oncogene.
特异性
This antibody recognizes Cbx7 at the C-terminus.
免疫原
GST-tagged recombinant protein corresponding to the C-terminus of mouse Cbx7.
Epitope: C-terminus
应用
Western Blot (Snap i.d.
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP.
Research Category
Epigenetics & Nuclear Function
Anti-Cbx7 Antibody is a Rabbit Polyclonal Antibody for detection of Chromobox protein homolog 7 (Cbx7) also known as hromobox protein homolog 7 & has been validated in WB & IP.
Research Sub Category
Chromatin Biology
质量
Evaluated by Western Blot in mouse embryonic stem cell lysate.
Western Blot Analysis: 0.25 ?g/mL of this antibody detected Cbx7 on 10 ?g of mouse embryonic stem cell lysate.
目标描述
~21 kDa observed. A non-specific band at ~ 44 kDa and may be observed in some lysates.
外形
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Mouse embryonic stem cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 纯化方式 | affinity chromatography |
| species reactivity | mouse |
| technique(s) | immunoprecipitation (IP): suitable western blot: suitable |
| NCBI登记号 | NP_659060 |
| UniProt登记号 | Q8VDS3 |
| 运输 | wet ice |
| Gene Information | human ... CBX7(23492) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
