您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor?488 conjugate

Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor?488 conjugate

品牌
Sigma-Aldrich
货号
06-519-AF488
规格纯度
from rabbit, ALEXA FLUOR?647
价格
5854.74 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor ?488 conjugate
Cyclic AMP-responsive element-binding protein 1 (pSer133), cAMP-responsive element-binding protein 1 (pSer133), CREB-1 (pSer133), CREB-A (pSer133), htCREB (pSer133), CREB-B (pSer119)
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation by various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species.

特异性

Recognizes phosphorylated CREB-A (pSer133), htCREB (pSer133), and CREB-B (pSer119) spliced isoforms reported by (UniProt P16220). May also recognize phosphorylated CREM and ATF-1 that contain homologous sequence to that of the immungen peptide.

免疫原

KLH-conjugated synthetic peptide corresponding to the amino acids including and encompassing phosphorylated Ser133 of CREB-A.
Epitope: pSer133.

应用

Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor?488 conjugate is an antibody against phospho-CREB for use in Immunofluorescence.
Research Sub Category
Transcription Factors
The unconjugated antibody (Cat. No. 06-519) is shown to be suitable also for Electrophoretic Mobility Shift Assay (EMSA), immunohistochemistry, and Western blotting applications.
Research Category
Epigenetics & Nuclear Function

质量

Evaluated by Immunofluorescence in rat brain tissue.

Immunofluorescence Analysis: A 1:50 dilution of this antibody detected phospho-CREB (Ser133) in rat brain tissue.

目标描述

~43 kDa observed.

外形

Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

法律信息

ALEXA FLUOR is a registered trademark of Life Technologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.45

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 ALEXA FLUOR?647
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
species reactivity human, mouse, rat
species reactivity (predicted by homology) Xenopus(based on 100% sequence homology), canine (based on 100% sequence homology), guinea pig (based on 100% sequence homology), chicken (based on 100% sequence homology), porcine (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s) immunofluorescence: suitable
同位素/亚型 IgG1
NCBI登记号 NP_604391
UniProt登记号 P16220
运输 wet ice
Gene Information human ... CREB1(1385)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map