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位置: 首页> 品牌> Sigma-Aldrich> Anti-Cyclin T1 Antibody

Anti-Cyclin T1 Antibody

品牌
Sigma-Aldrich
货号
06-1289
规格纯度
serum, from sheep
价格
5520.38 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Cyclin T1 Antibody
CDK9-associated C-type protein, Human immunodeficiency virus-1 expression, cyclin C-related protein, cyclin T1, cyclin T1b, human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1, subunit of positive elongation transcription factor b
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cyclin T1, which is also known as CCNT, is a member of the cyclin family and functions as a CDK kinase regulator. Cyclin T1 is one of regulatory cyclins (T1, T2a, T2b, and K) that is closely associated with CDK9 kinase forming a heterodimer called P-TEFb. This kinase complex is involved in phosporylating the carboxyl-terminal domain (CTD) of the large RNA polymerase II subunit which stimulate the elongation upon initiation. The cyclin T1/CDK9 complex has also been referred to as tat-associated kinase. Tat is an HIV protein that targets the cyclin T1/CDK9 complex to activate the transcription of the virus.

特异性

This antibody recognizes Cyclin T1.
Rat (85% sequence homology).

免疫原

Epitope: Unknown
His-tagged recombinant protein corresponding to human Cyclin T1.

应用

Research Sub Category
Cell Cycle, DNA Replication & Repair
Use Anti-Cyclin T1 Antibody (Sheep Polyclonal Antibody) validated in WB to detect Cyclin T1 also known as CDK9-associated C-type protein, cyclin C-related protein.
Research Category
Epigenetics & Nuclear Function
Western Blot Analysis: A 1:1000 dilution from a previous lot detected Cyclin T1 in 10 ?g of HEK293, HeLa, HepG2, Jurkat, and PC3 cell lysates.

质量

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected Cyclin T1 in 10 ?g of HeLa cell lysate.

目标描述

Cyclin T1 is expected to be ~85 kDa This antibody detects a ~85 kDa band in most cell lines. It also detects the degraded forms of Cyclin T1 (~70 kDa, ~60 kDa, et al), which is beneficial for IP applications. According to independent laboratory, this antibody can immunoprecipitate multiple forms of Cyclin T1.

外形

Unpurified
Sheep polyclonal serum with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
HeLa cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 sheep
抗体形式 serum
antibody product type primary antibodies
克隆 polyclonal
species reactivity human, mouse
technique(s) western blot: suitable
同位素/亚型 IgG
NCBI登记号 NP_001231.2
UniProt登记号 O60563
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1

Sigma-Aldrich

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