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Anti-CDK5RAP2 Antibody

品牌
Sigma-Aldrich
货号
06-1398
规格纯度
from rabbit, purified by affinity chromatography
价格
5016.79 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-CDK5RAP2 Antibody
CDK5 regulatory subunit-associated protein 2, CDK5 activator-binding protein C48, Centrosome-associated protein 215
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Also known as Cep215, CDK5RAP2 is involved in a variety of cellular processes. It serves as a potential regulator of CDK5 activity through its interaction with CDK5R1. It acts as a negative regulator of centriole disengagement, which maintains centriole engagement and cohesion. It is involved in the regulation of mitotic spindle orientation. Additionally, this protein mediates spindle checkpoint activation by serving as a transcriptional regulator of the MAD2 and BUBR1 promoter. In conjuction with MAPRE1, CDK5RAP2 promotes microtubule polymerization, bundle formation, and growth at the plus ends. It also plays a role in DNA damage-induced G2 cell cycle checkpoint. CDK5RAP2 is known to be mutated in primary microcephaly, a neuodevelopmental disorder that is characterized by a decrease in brain size.

特异性

Other Homologies: Rat (83% sequence homology) and Mouse (82% sequence homology).

免疫原

MBP-tagged recombinant protein corresponding to human CDK5RAP2.

应用

Use Anti-CDK5RAP2 Antibody (rabbit polyclonal antibody) validated in WB, ICC to detect CDK5RAP2 also known as CDK5 regulatory subunit-associated protein 2, CDK5 activator-binding protein C48, Centrosome-associated protein 215.
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected CDK5RAP2 in RPE1 cells. (Barr, A.R., et al. (2010). J Cell Biol. 189(1):23-39.)

质量

Evaluated by Western Blot in 10 ?g of HeLa cell lysate.

Western Blot Analysis: A 1:2,500 dilution of this antibody dectected CDK5RAP2 in 10?g of HeLa cell lysate.

目标描述

~220 kDa observed. Uniprot.org states four isoforms produced by alternative splicing, which may be observed at a molecular weight of ~216 kDa, ~211 kDa, ~210 kDa, and ~206 kDa in some cell lysates.

外形

Affinity purified

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunocytochemistry: suitable
western blot: suitable
NCBI登记号 NP_001011649
UniProt登记号 Q96SN8
运输 wet ice
Gene Information human ... CDK5RAP2(55755)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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