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位置: 首页> 品牌> Sigma-Aldrich> Rabbit anti-HSP60 Antibody, Affinity Purified

Rabbit anti-HSP60 Antibody, Affinity Purified

品牌
Sigma-Aldrich
货号
PLA0269
规格纯度
Powered by Bethyl Laboratories, Inc.
价格
6227.32 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Rabbit anti-HSP60 Antibody, Affinity Purified
chaperonin 60
HSP60
Heat shock protein 60
HLD4
short heat shock protein 60 Hsp60s1
HSP65
heat shock 60kDa protein 1 (chaperonin)
HuCHA60
heat shock 60kD protein 1 (chaperonin)
60 kDa chaperonin
GroEL
heat shock protein 65
spastic paraplegia 13 (autosomal dominant)
mitochondrial matrix protein P1
HSP-60
CPN60
SPG13
P60 lymphocyte protein
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The HSPD1 (heat shock protein family D member 1) gene encodes the HSP60 (heat shock protein 60) subunit of the HSP60/HSP10 chaperonin complex. The HSPD1 gene consisting of 12 exons is localized to human chromosome 2q33.1.

免疫原

The epitope recognized by PLA0269 maps to a region between residue 250 and 300 of human Heat Shock Protein 60 using the numbering given in entry NP_002147.2 (GeneID 3329).

生化/生理作用

The protein encoded by the HSPD1 (heat shock protein family D member 1) gene forms a double-barrel chaperonin complex with heat shock protein 10 (HSP10). This chaperonin complex facilitates folding of proteins to their native state in the mitochondrial matrix space. Missense mutation in the HSP60 gene has been associated with a rare dominant form of hereditary spastic paraplegia and a recessively inherited white matter disorder called MitCHAP60 disease.
HSP60 is also found to interact with the transcription factor interferon regulatory factor 3 (IRF3), which is involved in the induction of IFN-β (interferon- β) signaling pathway, a crucial host-protective response.

外形

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

其他说明

Heat shock protein 60 (HSP60) is a member of the chaperonin family. HSP60 is a mitochondrial protein that may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. [taken from NCBI Entrez Gene (GeneID: 3329)].

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity purified immunoglobulin
antibody product type primary antibodies
等级 Powered by Bethyl Laboratories, Inc.
species reactivity human, mouse
technique(s) immunohistochemistry: 1:200- 1:1,000
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000
登记号 NP_002147.2
运输 wet ice
储存温度 2-8℃
Gene Information rabbit ... HSP60(3329)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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