半岛bd体育手机客户端 说明
一般描述
The HSPD1 (heat shock protein family D member 1) gene encodes the HSP60 (heat shock protein 60) subunit of the HSP60/HSP10 chaperonin complex. The HSPD1 gene consisting of 12 exons is localized to human chromosome 2q33.1.
免疫原
The epitope recognized by PLA0269 maps to a region between residue 250 and 300 of human Heat Shock Protein 60 using the numbering given in entry NP_002147.2 (GeneID 3329).
生化/生理作用
The protein encoded by the HSPD1 (heat shock protein family D member 1) gene forms a double-barrel chaperonin complex with heat shock protein 10 (HSP10). This chaperonin complex facilitates folding of proteins to their native state in the mitochondrial matrix space. Missense mutation in the HSP60 gene has been associated with a rare dominant form of hereditary spastic paraplegia and a recessively inherited white matter disorder called MitCHAP60 disease.
HSP60 is also found to interact with the transcription factor interferon regulatory factor 3 (IRF3), which is involved in the induction of IFN-β (interferon- β) signaling pathway, a crucial host-protective response.
外形
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
其他说明
Heat shock protein 60 (HSP60) is a member of the chaperonin family. HSP60 is a mitochondrial protein that may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. [taken from NCBI Entrez Gene (GeneID: 3329)].
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity purified immunoglobulin |
antibody product type | primary antibodies |
等级 | Powered by Bethyl Laboratories, Inc. |
species reactivity | human, mouse |
technique(s) | immunohistochemistry: 1:200- 1:1,000 immunoprecipitation (IP): 2-5 μg/mg western blot: 1:2,000- 1:10,000 |
登记号 | NP_002147.2 |
运输 | wet ice |
储存温度 | 2-8℃ |
Gene Information | rabbit ... HSP60(3329) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich