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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-LRRC8A antibody produced in mouse

Monoclonal Anti-LRRC8A antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1412855
规格纯度
clone 8H9, purified immunoglobulin
价格
6644.93 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-LRRC8A antibody produced in mouse
Anti-FLJ10337
Anti-FLJ41617
Anti-LRRC8
Anti-KIAA1437
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. (provided by RefSeq)
Leucine rich repeat containing eight family member A (LRRC8A) is a 94 kDa LRR-containing protein, encoded by the gene mapped to human chromosome 9q34.11. The encoded protein is ubiquitously expressed, but at higher levels on the surface of thymocytes than on other immune cells.

免疫原

LRRC8A (NP_062540.2, 711 a.a. ~ 810 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
QNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERLWRADKEQA

生化/生理作用

Leucine rich repeat containing eight family member A (LRRC8A) plays an important role in T cell development, survival and function. It also plays an essential role in B-cell development. In mouse, mutation in the gene leads to abnormalities of B cell development. In addition, mutation in the gene is also associated with the development of non-Bruton type agammaglobulinemia in humans.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 8H9, monoclonal
形式 buffered aqueous solution
分子量 antigen 36.74 kDa
species reactivity human
technique(s) ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2a
GenBank?accession no. NM_019594
UniProt登记号 Q8IWT6
运输 dry ice
储存温度 ?20℃
Gene Information human ... LRRC8A(56262)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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