Anti-MBNL1 Antibody

半岛bd体育手机客户端 说明

一般描述

Muscleblind 1 (MBNL1) is a member of the muscleblind family. MBNL1in involved in pre-mRNA alternative splicing and acts as either splicing activator or repressor on specific pre-mRNA targets. This protein contains four C3H1-type zinc fingers and binds to expanded CUG repeat RNA. High expression of MBNL1 has been observed in cardiac and skeletal muscle as well as in differentiating myoblasts. MBNL1 is known to be involved in the pathogenesis of dystrophia myotonica type 1 (DM1). For those afflicted with this muscular disorder, MBNL1 is sequestered by DMPK RNAs that contain CUG triplet repeat expansions.

免疫原

Histidine-tagged recombinant protein corresponding to human MBNL1.

应用

Research Category
Epigenetics & Nuclear Function
Use Anti-MBNL1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect MBNL1 also known as muscleblind-like (Drosophila), Triplet-expansion RNA-binding protein.
Research Sub Category
RNA Metabolism & Binding Proteins

质量

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 1 ?g/mL of this antibody detected MBNL1 on 10 ?g of A431 cell lysate.

目标描述

~ 33-42 kDa observed. There are three known splice variants ranging from ~33 kDa to ~42 kDa An uncharacterized band at ~ 80 kDa has been observed in some lysates.

外形

Purified rabbit polyclonal in tris-citrate containing 0.1% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
A431 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	rat, human, mouse
technique(s)	western blot: suitable
NCBI登记号	NP_066368
UniProt登记号	Q9NR56
运输	wet ice
Gene Information	human ... MBNL1(4154)

安全信息

储存分类代码

10 - Combustible liquids