Anti-PGAM5 Antibody

半岛bd体育手机客户端 说明

一般描述

PGAM5 is a mitochondrial specific phosphatase specific for serine/threonine residues. PGAM5 principally dephosphorylates and activates MAP3K5 kinase a critical player in many cancers. PGAM5 also acts as a central mediator for programmed necrosis or necroptosis, induced by TNF, ROS or calcium. In the mitochondria, PGAM5 may also function as a regulator of mitochondrial dynamics and reconstruction. Also PGAM5 functions in the cellular stress response and regulates the removal of damaged mitochondria via mitophagy. PGAM5 itself is regulated at the protein level by the mitochondrial specific rhomboid protease PARL, which cleaves the N-terminal of PGAM5 in response to mitochondrial depolarization.

特异性

This antibody detects the -L(long) isoform and -S(short) isoform of PGAM5.

免疫原

Epitope: Near N-terminal
KLH-conjugated linear peptide corresponding to human PGAM5 near the N-terminal.

应用

Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
This Anti-PGAM5 Antibody is validated for use in Western Blotting for the detection of PGAM5.

质量

Evaluated by Western Blotting in HT-29 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected PGAM5 in 10 ?g of HT-29 cell lysate.

目标描述

~32/34 kDa observed.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
species reactivity (predicted by homology)	chimpanzee (based on 100% sequence homology), hamster (based on 100% sequence homology), monkey (based on 100% sequence homology), primate (based on 100% sequence homology), rodent (based on 100% sequence homology)
technique(s)	western blot: suitable
NCBI登记号	NP_001164014
UniProt登记号	Q96HS1
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable