半岛bd体育手机客户端 说明
一般描述
Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. The gene encoding this protein is localized on human chromosome 10p13.
免疫原
The epitope recognized by PLA0199 maps to a region between residue 416 and 466 of human vimentin using the numbering given in entry NP_003371.2 (GeneID 7431).
生化/生理作用
Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.
外形
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
其他说明
Vimentin is an intermediate filament expressed mainly in mesenchymal tissue and in primitive (undifferentiated) non-mesenchymal cells. It is a Class III cytoplasmic filament that forms a dense cytoskeletal network that extends from the nucleus to the plasma membrane. Vimentin reorganization during mitosis is likely regulated via its multiple phosphorylation sites. Vimentin expression is also found in mesoderm derived epithelia. Immunohistochemistry (IHC) with anti-vimentin antibodies is often used to identify neoplasms of mesenchymal or mesodermal origin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| 等级 | Powered by Bethyl Laboratories, Inc. |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry: 1:200-1:1,000 western blot: 1:2,000- 1:10,000 |
| 登记号 | NP_003371.2 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | rabbit ... Vimentin(7431) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
