半岛bd体育手机客户端 说明
一般描述
Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10R is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10R mediated signalling is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Monoclonal Anti-Interleukin-10 Receptor α (IL-10 Rα) recognizes human IL-10 Rα. The antibody does not cross-react with recombinant mouse IL-10 Ra.
特异性
The antibody has the ability to block cell surface human IL-10 Rα mediated bioactivity induced by recombinant human IL-10. The antibody does not cross-react with mouse IL-10 Rα.
免疫原
purified recombinant human IL-10 soluble receptor α expressed in insectSf21 cells.
应用
Anti-interleukin-10 receptor α antibody is suitable for neutralization reactions (ND50 is 0.03-0.1 μg/ml).
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD03792423 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 37607, monoclonal |
| 形式 | lyophilized powder |
| species reactivity | human |
| technique(s) | neutralization: suitable |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | Q13651 |
| 储存温度 | ?20℃ |
| Gene Information | human ... IL10RA(3587) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
