半岛bd体育手机客户端 说明
一般描述
The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.
特异性
Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.
免疫原
Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.
生化/生理作用
γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).
特点和优势
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外形
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | S87-25, monoclonal |
| 形式 | buffered aqueous glycerol solution |
| 分子量 | antigen predicted mol wt 55 kDa |
| species reactivity | mouse, human, rat |
| 浓度 | 1 mg/mL |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NP_032097.1 |
| UniProt登记号 | P28472 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | mouse ... Gabrb3(14402) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
