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Anti-SAPAP1 Antibody

品牌
Sigma-Aldrich
货号
ABN309
规格纯度
from rabbit, purified by affinity chromatography
价格
6190.47 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-SAPAP1 Antibody
SAP90, PSD-95-associated protein 1, Disks large-associated protein 1, DLGAP1, DAP-1, GKAP
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PSD-95/SAP90-binding protein 1 (SAPAP1) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP1 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1 mRNA is targeted to cell bodies in a similar manner to SAPAP2 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM).

特异性

At least three isoforms of SAPAP1 are known to exist. This SAPAP1 antibody will not cross-react with other SAPAP proteins.

免疫原

KLH-conjugated linear peptide corresponding to human SAPAP1.

应用

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SAPAP1 in human brain tissue.
This SAPAP1 antibody is validated for use in WB & IHC for the detection of the SAPAP1 protein.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

质量

Evaluated by Western Blot in human brain tissue lysate.

Western Blot Analysis: 1 ?g/mL of this antibody detected SAPAP1 in 10 ?g of human brain tissue lysate.

目标描述

~95 kDa observed. Uniprot describes 7 isoforms ranging between ~70 and ~109 kDa An uncharacterized band may appear at ~58 kDa in some lysates. The calculated molecular weight is 109 kDa, however SAPAP1 has been shown as a ~95 kDa band in western blots. (Naisbitt, S., et al. (1997). 17(15):5687-5696.)

外形

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human brain tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunohistochemistry: suitable
western blot: suitable
UniProt登记号 O14490
运输 wet ice
Gene Information human ... DLGAP1(9229)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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