Anti-RYR2 antibody produced in rabbit

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一般描述

RYR2 (ryanodine receptor 2) is an intracellular Ca²⁺release channel present on the sarcoplasmic reticulum (SR). It forms tetramer with four types 2 RyR polypeptides (RyR2) and four FK506 binding proteins (FKBP12.6).
Anti-RYR2 Antibody detects endogenous levels of total RYR2 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human RyR2.

Immunogen Range:2774-2823

应用

Anti-RYR2 antibody produced in rabbit is suitable for immunohistochemistry and indirect ELISA.

生化/生理作用

RYR2 (ryanodine receptor 2) provides guidance to the release and transport of Ca²⁺from sarcoplasmic reticulum (SR) to the cytoplasm during cardiac muscle excitation-contraction (EC) coupling. Protein kinase A (PKA) phosphorylated RYR2 separates (FKBP12.6) to regulate the channel open probability (Po). During the process, a small portion of Ca²⁺enter into the cell through the L-type Ca²⁺channel, which further activates the RyR2 channel upon membrane depolarization. The activated RyR2 channel releases a large amount of Ca²⁺from the SR and subsequent muscle contraction. Missense mutations in this gene cause Kazakh idiopathic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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