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Anti-IGPR-1 Antibody

品牌
Sigma-Aldrich
货号
ABC74
规格纯度
1 mg/mL, from rabbit
价格
5854.74 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-IGPR-1 Antibody
Transmembrane and immunoglobulin domain-containing protein 2, Immunoglobulin and proline-rich receptor 1, IGPR-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

IGPR-1 or Immunoglobulin and proline-rich receptor 1, also called Transmembrane and immunoglobulin domain-containing protein 2 and encoded by the human gene TMIGD2/IGPR1 is a widely expressed epithelial and endothelial membrane protein that plays a role in cell-cell interactions, cell migration and angiogenesis. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and in B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel β2.

免疫原

Linear peptide corresponding to the cytoplasmic domain of the human mature form of IGPR-1.
Epitope: Cytoplasmic domain

应用

Western Blotting Analysis: 2 ?g/mL from a representative lot detected IGPR-1 in 10 ?g of HepG2 cell lysate, human placenta tissue lysate, HUVEC cell lysate, and L9 cell lysate.

Western Blotting Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cell lysates (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cells (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in human colon cancer tissues (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).
Research Sub Category
Apoptosis - Additional
Anti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in PC-12 cell lysate.

Western Blotting Analysis: 2 ?g/mL of this antibody detected IGPR-1 in 10 ?g of PC-12 cell lysate.

目标描述

~58 kDa observed. Uniprot describes two isoforms at 31 kDa and 30 kDa The pre-mature and mature form of this protein may be observed at 32 kDa and 58 kDa (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.). Uncharacterized band(s) may be observed in some cell lysates.

外形

Format: Purified
Protein A purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 purified antibody
antibody product type primary antibodies
克隆 polyclonal
species reactivity rat, human
浓度 1 mg/mL
technique(s) immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NP_001162597
UniProt登记号 Q96BF3
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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