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Anti-CXCR3 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C1366
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
4330.86 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-CXCR3 antibody produced in rabbit
Anti-CXC Chemokine Receptor 3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Chemokines bind to specific G protein-coupled cell surface receptors on target cells. Five CXC receptors (CXCR1-5), nine CC receptors (CCR1-9) and one CXXXC receptor (CX3CR1) have been cloned to date. Expression of chemokine receptors can be restricted to some cell types (CXCR1 is expressed in neutrophils) while others (such as CCR2) are expressed in a wide variety of cells. CXCR-3, also known as the IP-10/Mig receptor, shares approximately 40% protein sequence idENTITY_TYPE_CODE with CXCR-1 and CXCR-2, and 34.2-36.9% amino acid sequence idENTITY_TYPE_CODE with the five known CC chemokine receptors 1-5. CXCR-3 is highly expressed by IL-2-activated T lymphocytes (Th1), but not by resting T lymphocytes, B lymphocytes, monocytes or granulocytes. CXCR-3 binds IP-10 and Mig (but not PF4) with high affinity and mediates Ca2+mobilization and chemotaxis. CXCR-3 does not bind any of the CXC chemokines containing the ELR motif. CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseases including atheroslerosis, Alzheimer′s, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.
Rabbit polyclonal anti-CXCR3 antibody specifically recognizes human CXC Chemokine Receptor 3 by immunohistochemistry with formalin-fixed, paraffin embedded tissues. Not tested for other uses. The immunizing peptide has 82% homology with the rat and mouse gene. Other species reactivity has not been confirmed.

免疫原

synthetic peptide corresponding to the C-terminus of human CXC chemokine receptor 3 (CXCR3), conjugated to KLH. The immunizing peptide has 82% homology with the rat and mouse gene.

应用

Rabbit polyclonal anti-CXCR3 antibody is used to tag CXC Chemokine Receptor 3 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of CXC Chemokine Receptor 3 in processes such as the mediation of Ca2+mobilization and chemotaxis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

外形

Solution in phosphate buffered saline containing 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01864634
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 16 μg/mL
UniProt登记号 P49682
运输 dry ice
储存温度 ?20℃
Gene Information human ... CXCR3(2833)
mouse ... Cxcr3(12766)
rat ... Cxcr3(84475)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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