Anti-CNDP1 antibody produced in rabbit

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一般描述

CNDP1 (carnosine dipeptidase 1) is a secreted protein, which is found in human blood and central nervous system (CNS). It has a molecular weight of 57kDa and functions as a homodimer. It is anN-glycosylated glycoprotein. It is also found in liver and belongs to the M20 metallopeptidase family.

免疫原

Beta-Ala-His dipeptidase precursor recombinant protein epitope signature tag (PrEST)

应用

Anti-CNDP1 antibody produced in rabbit is used for sandwich immunoassay.
Anti-CNDP1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

CNDP1 (carnosine dipeptidase 1) functions as a carboxypeptidase and dipeptidase and is responsible for the degradation of carnosine and homocarnosine. It forms a complex with α-2 macroglobulin, which is a protease inhibitor. In type 2 diabetes, this gene is linked with susceptibility to nephropathy. Its reduced serum levels are linked with aggressiveness of prostate cancer. Reduced levels are also associated with lymph node metastasis. Its circulating levels are also decreased in glioblastoma, and in gastrointestinal cancer this is linked with poor outcome. Thus, it might be a putative maker for aggressive cancer and colorectal cancer.

特点和优势

Prestige Antibodies^?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST71587.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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