Anti-BTG3 Antibody

半岛bd体育手机客户端 说明

一般描述

BTG3 is a tumor suppression protein because overexpression impairs serum-induced cell cycle progression from G0/G1 to the S phase in vitro. BTG3 is often down regulated in cancer cell lines, and thus BTG3 is a target for enhanced cancer therapy. In normal cells BTG3 inhibits cell proliferation, cell invasion, and angiogenesis, and also regulates cell-cycle progression and differentiation in a variety of cell types. Developmentally BTG3 is normally expressed primarily in the brain and CNS during development where is modulates cell proliferation. In the adult expression is high in ovary, testis, prostate, thymus and lung. It is not expressed strongly in many cancers.

特异性

This antibodies immunogen is 94% identical in mouse and 92% identical in rat.

免疫原

GST-tagged recombinant protein corresponding to human BTG3.

应用

Research Sub Category
Apoptosis - Additional
This Anti-BTG3 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of BTG3.
Research Category
Apoptosis & Cancer
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BTG3 in human testis and human prostate tissue.

质量

Evaluated by Western Blotting in IMR-90 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected BTG3 in 10 ?g of IMR-90 cell lysate.

目标描述

~37 kDa observed. Uncharacterized bands may be observed in some lysates. The calculated molecular weight of this protein is 29 kDa, but can be observed at ~37 kDa due to alternate splice variants.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
NCBI登记号	NP_006797
UniProt登记号	Q14201
运输	wet ice
Gene Information	human ... BTG3(10950)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable