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Anti-TDP-43 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
T1705
规格纯度
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
6923.34 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-TDP-43 antibody produced in rabbit
Anti-TARDBP
Anti-Tar DNA binding protein 43
Anti-ALS10
Anti-TARDP43
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TDP-43 (TAR DNA binding protein, TARDP) is encoded by the gene mapped to human chromosome 1p36.22. The encoded protein belongs to the family of heterogenous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is a 414 amino acid nuclear protein and is widely expressed in a variety of tissues.

特异性

Anti-TDP-43 specifically recognizes human, mouse, and rat TDP-43.

生化/生理作用

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are involved in the generation and processing of RNA, including transcription, splicing, transport and stability. TDP-43 regulates transcription of human immunodeficiency virus (HIV). The protein is identified as a major pathological protein, in both frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Abnormal phosphorylation of TDP-43 at Ser409/410 has also been observed in FTLD-U and ALS, suggesting a toxic gain of function leading to apoptosis.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses,in vitrodiagnostic uses,ex vivoorin vivotherapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~43 kDa
species reactivity rat, human, mouse
浓度 ~1.5 mg/mL
technique(s) immunohistochemistry: 5-10 μg/mL using rat, mouse or human kidney
indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells
western blot: 1.5-3.0 μg/mL using human U2OS cell lysates
UniProt登记号 Q13148
运输 dry ice
储存温度 ?20℃
Gene Information human ... TARDBP(23435)

Sigma-Aldrich

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