Anti-TCF12 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Transcription factor 12 (TCF12) is a class I member of helix-loop-helix (HLH) protein family, encodes for class II basic helix-loop-helix protein (bHLHb) transcription factor. In human chromosome, the gene TCF12 is localized on 15q21.3.

免疫原

TCF12 antibody was raised against a 19 amino acid peptide near the amino terminus of human TCF12.

应用

Anti-TCF12 antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Transcription factor 12 (TCF12) represses E-cadherin expression and thereby controls metastasis of colorectal cancer cells. TCF12 might play a role in controlling the proliferation of neural stem cells and progenitor cells. TCF12-TWIST1 (twist family bHLH transcription factor 1) heterodimers is required for the development of normal coronal suture. Mutations in the TCF12 heterodimer causes coronal craniosynostosis. TCF12 is critically required for regulating human mesodermal and hematopoietic specification in the early development. Mutations in TCF12 affects the transcriptional activity and leads to anaplastic oligodendroglioma, a rare brain tumor.

特点和优势

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联系

The action of this antibody can be blocked using blocking peptide SBP3500566.

外形

Supplied in PBS with 0.02% sodium azide.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
species reactivity	mouse, rat, human
technique(s)	immunocytochemistry: suitable indirect ELISA: suitable western blot: suitable
NCBI登记号	AAH50556
UniProt登记号	Q99081
运输	dry ice
储存温度	?20℃
Gene Information	human ... TCF12(6938)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable