Anti-phospho-DNA-PK (pSer²⁰⁵⁶) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Protein kinase, DNA-activated, catalytic polypeptide (PRKDC), also known as DNAPK, is encoded by the gene mapped to human chromosome 8q11. PRKDC is characterized by a large catalytic polypeptide and DNA-binding component comprised of the Ku70 and Ku80 heterodimer, that targets DNA-PKc, to DNA.

免疫原

The antiserum was produced against synthesized peptide derived from human DNA-PK around the phosphorylation site of Ser2056.

Immunogen Range:2022-2071

应用

Anti-phospho-DNA-PK (pSer2056) antibody produced in rabbit has been used in immunofluorescence analysis.

生化/生理作用

Protein kinase, DNA-activated, catalytic polypeptide (PRKDC), also known as DNAPK, plays an essential role in the colorectal cancer (CRC) cell proliferation/survival. Therefore, it can be used as a potential prognostic biomarker and a therapeutic target for CRC. Decreased expression of PRKDC influences apoptosis partially by inhibiting AKT activation. Overexpression of activated DNAPK elevates the expression of rearranged during transfection (RET), which is a proto-oncogene involved in the development of medullary thyroid cancer (MTC). DNAPK plays a crucial role in non-homology end joining (NHEJ) pathway. Downregulation of DNAPK enhances anticancer drug induced DNA damage repair in osteosarcoma cell line MG63.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen 469 kDa
species reactivity	mouse, rat, human
浓度	~1 mg/mL
technique(s)	ELISA: 1:10000 immunohistochemistry: 1:50-1:100
NCBI登记号	P78527
UniProt登记号	P78527
运输	wet ice
储存温度	?20℃
Gene Information	human ... PRKDC(5591)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable