您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-MCPH1 Antibody

Anti-MCPH1 Antibody

品牌
Sigma-Aldrich
货号
ABN404
规格纯度
from rabbit, purified by affinity chromatography
价格
5688.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-MCPH1 Antibody
Microcephalin
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The protein named Microcephalin and encoded by the human gene named MCPH1 is a DNA/chromatin binding protein implicated in chromosome condensation and DNA damage induced cellular responses. MCPH1 plays a role in neurogenesis and is involved in the regulation of the size of the cerebral cortex. MCPH1 interacts with several proteins including H2AFX under DNA damage conditions and CDC27 during normal cell growth. MCPH1 is expressed cytoplasmically in a variety of cell types and tissues and is particularly expressed in the fetal brain, liver and kidney. Defects in MCPH1 can give rise to microcephaly a disease where the head circumference is markedly reduced and effected patients are mentally retarded, showing a high number of prophase-like cells in cytological examinations. In addition, cell divisions are irregular and demonstrate a delay in post-mitotic chromosome decondensation. Interestingly, recent research demonstrates that MCPH1 also functions as a tumor suppressor that is regulated by the microRNA miR-27a.

免疫原

KLH-conjugated linear peptide corresponding to human MCPH1.

应用

Anti-MCPH1 Antibody is a highly specific rabbit polyclonal antibody, that targets Microcephalin & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected MCPH1 in human cerebellum, human testis, and human cerebral cortex tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in human testis tissue lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected MCPH1 in 10 ?g of human testis tissue lysate.

目标描述

~111 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NP_078872
UniProt登记号 Q8NEM0
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map