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Anti-Fibrillin-1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4500863
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-Fibrillin-1 antibody produced in rabbit
MFS1
FBN
MASS
fibrillin-1
M350 kda glycoprotein component extracellular microfibril
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Fibrillin-1 is a multidomain cysteine-rich glycoprotein that belongs to the fibrillin protein family. It is encoded by the FBN1 gene mapped to human chromosome 15q21. Fibrillin-1 structure includes 43 calcium-binding epidermal growth factor (cbEGF)–like domains and 78 cysteine-containing TB motifs. The protein is ubiquitously present and is a vital component of elastic fiber–associated microfibrils in connective tissues. Anti-Fibrillin-1 Antibody detects endogenous levels of total Fibrillin-1 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human Fibrillin-1.

Immunogen Range:2811-2860

应用

Anti-Fibrillin-1 antibody produced in rabbit has been used in immunohistochemical staining (1:50).

生化/生理作用

Fibrillin-1 protein plays an important role in the fibrillogenesis in elastic tissues and non-elastic tissues. It acts as an anchoring fiber and induces Smad2 signaling by regulating the bioavailability of endogenous transforming growth factor β1 (TGF-β1). Mutation in the FBN1 gene leads to the development of heritable disorder Marfan syndrome. Mutation of this gene also causes thoracic aortic aneurysms in patients without Marfan syndrome.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD02262898
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 312 kDa
species reactivity mouse, rat, human
浓度 ~1 mg/mL
technique(s) ELISA: 1:40000
immunohistochemistry: 1:50-1:100
NCBI登记号 P35555
UniProt登记号 P35555
运输 wet ice
储存温度 ?20℃
Gene Information human ... FBN1(2200)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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