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Anti-CCR7 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4500329
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-CCR7 antibody produced in rabbit
C-C chemokine receptor type 7
CCR-7
MIP-3 β receptor
CC-CKR-7
C-C CKR-7
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

C-C motif chemokine receptor 7 (CCR7) also known as EBI1, is encoded by the gene mapped to human chromosome 17q12-q21.2. The encoded protein is a member of chemokine receptor family and is expressed mainly by B cells, T cells, and on activated mature dendritic cells (DCs).
CCR7 is a G protein-coupled seven-transmembrane domain receptor. It has two high-affinity ligands, secondary lymphoid chemokine (SLC) and EB11-ligand chemokine (ELC).

免疫原

The antiserum was produced against synthesized peptide derived from human CCR7.

Immunogen Range:170-219

应用

Anti-CCR7 antibody produced in rabbit has been used in immunofluorescence (1:50).
Anti-CCR7 antibody produced in rabbit has been used for proximity ligation assay (PLA).

生化/生理作用

C-C motif chemokine receptor 7 (CCR7) harmonizes the antigen-specific immune response by combining T cells, B cells, and dendritic cells (DCs), to form functional microenvironments in the secondary lymphoid organs. CCR7 controls trafficking of skin DC under both inflammatory and steady-state conditions. This protein is also involved in emigration pathway of mature DCs from the skin to regional lymph nodesin vivo. CCR7 oligomers function acts as a scaffolds to link distinct signaling pathways for cell migration. Interaction of CCR7 with its ligand, CCL21/6ckine is essential for preferential lymph node metastasis of gastric carcinoma.
CCR7 can stimulate the development of hepatocellular carcinoma (HCC). In human malignancies, CCR7 may act as an initiator of epithelial-mesenchymal transition (EMT).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD03455130
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 42 kDa
species reactivity human
浓度 ~1 mg/mL
technique(s) ELISA: 1:40000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号 P32248
UniProt登记号 P32248
运输 wet ice
储存温度 ?20℃
Gene Information human ... CCR7(1236)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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