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Anti-BRD2 Antibody

品牌
Sigma-Aldrich
货号
ABE477
规格纯度
from rabbit, purified by affinity chromatography
价格
5688.25 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-BRD2 Antibody
Bromodomain-containing protein 2, O27.1.1, Really interesting new gene 3 protein
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Bromodomain-containing protein 2 (BRD2) is a member of the BET subfamily of bromodomain proteins. These proteins contain two tandem N-terminal bromodomains and a single C-terminal extra-terminal domain. Studies have shown BRD2 to be associated with several regulators of transcription (eg. TFIID and Swi/Snf complexes) in addition to its involvement in guiding cell cycle gene expression through its binding to multiple E2F. BRD2 is hypothesized to function in mammalian development by regulating chromatin structure and transcription. Consistent with this hypothesis, studies have shown BRD2 to bind histone H4 via acetylated Lys12. BRD2 mutants have been associated with increased susceptibility to juvenile myoclonic epilepsy.

特异性

This antibody is expected to cross react with isoforms 1 and 2 of BRD2, based upon sequence homology.

免疫原

GST-tagged recombinant protein corresponding to a region near the C-terminus of human BRD2.

应用

Anti-BRD2 Antibody is a highly specific rabbit polyclonal antibody, that targets BRD2 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:500 dilution of this antibody from a representative lot detected BRD2 in human testis tissues.

Immunohistochemistry Analysis: A 1:2,000 and a 1:500 dilution from a representative lot detected BRD2 in rat testis tissues.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

质量

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 0.25 ?g/mL of this antibody detected BRD2 in 10 ?g of Jurkat cell lysate.

目标描述

~110 kDa observed. Uniprot describes two isoforms at 88 kDa (isoform 1) and 92 kDa (isoform 2). Uncharacterized band(s) may be observed in some cell lysates.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human, rat
technique(s) immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NP_001106653.1
UniProt登记号 P25440
运输 wet ice
Gene Information human ... BRD2(6046)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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