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位置: 首页> 品牌> Sigma-Aldrich> Anti-Sirt1 (C-terminal) 兔抗

Anti-Sirt1 (C-terminal) antibody produced in rabbit

Anti-Sirt1 (C-terminal) 兔抗

品牌
Sigma-Aldrich
货号
S5322
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
4574.61 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Sirt1 (C-terminal) antibody produced in rabbit
Anti-SIR2α
Anti-SIR2
Anti- S. cerevisiae, HOMOLOG-LIKE 1
Anti-SIR2L1
Anti-Sirtuin 1
Anti-Sirt1 (C-terminal) 兔抗
Anti-SIR2-α
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SIRT1 (sirtuin 1) belongs to the silent information regulator (SIR) 2 family and is a class to HDAC (histone deacetylase). It is expressed in various tissues including brain, liver, pancreas, adipose tissue, and skeletal muscle. SIRT1 is also known as the longevity gene.
Sirtuin-1 (SIRT1) resides in the nucleus.

免疫原

synthetic peptide corresponding to amino acids 723-736 of human SIRT1, conjugated to KLH via an N-terminal cysteine residue.

应用

Anti-Sirt1 (C-terminal) antibody has been used in

  • immunoblotting
  • immunoprecipitation
  • immunofluorescence
  • immunohistochemistry
  • western blotting

生化/生理作用

SIRT1 (sirtuin 1) functions as a regulator of various metabolic pathways, and influences the pathophysiology of several metabolic diseases. It is a regulator of protein deacetylation, and is a candidate therapeutic target in non-alcoholic fatty liver disease (NAFLD), amyotrophic lateral sclerosis (ALS), kidney disease, and pulmonary disease. It also participates in tumorigenesis, and whether it functions as an oncogene or as a tumor suppressor depends upon the tumor type. In ancreatic ductal adenocarcinoma (PDAC) its elevated expression is linked with poor prognosis, and innon-small-cell lung cancer (NSCLC) it suppresses the expression of tumor suppressor p27. It is also thought to function as a suppressor of cardiovascular disorders, such as myocardial infarction, or neurodegenerative diseases, such as Alzheimer′s disease (AD) or Parkinson′s disorder (PD).
Sirtuin-1 (SIRT1) is a NAD-dependent deacetylase which has been implicated in the regulation of several transcription factors, including p53, forkhead box protein O (FOXO), nuclear factor kappa-B (NFκB), myocyte-specific enhancer factor 2 (Mef2), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α).

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD08705602
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~120 kDa
species reactivity human
浓度 ~1.0 mg/mL
technique(s) immunoprecipitation (IP): 5-10 μg using extracts of Jurkat cells
indirect immunofluorescence: 10-20 μg/mL using human U-2-OS cells
western blot: 1-2 μg/mL using whole extracts of Jurkat cells
UniProt登记号 Q96EB6
运输 dry ice
储存温度 ?20℃
Gene Information human ... SIRT1(23411)
mouse ... Sirt1(93759)
rat ... Sirt1(309757)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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