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Anti-DAPK1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4500620
规格纯度
affinity isolated antibody
价格
4618.16 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-DAPK1 antibody produced in rabbit
kinase DAPK1
DAPK
Death associated protein kinase
DAP kinase 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Anti-DAPK1 Antibody detects endogenous levels of total DAPK1 protein.
Death associated protein kinase 1 (DAPK1) is a calcium/calmodulin–regulated (CaM-regulated) protein kinase that belongs to the kinases family. The protein structure contains a kinase domain, a CaM binding domain, eight ankyrin repeats, and a death domain. DAPK1 protein is encoded by the gene mapped to human chromosome 9q21.33. Anti-DAPK1 antibody detects endogenous levels of total DAPK1 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human DAPK1.

Immunogen Range:274-323

应用

Anti-DAPK1 antibody produced in rabbit has been used in:

  • immunohistochemistry(1:400 )
  • coimmunoprecipitation
  • immunoblot

生化/生理作用

Death associated protein kinase 1 (DAPK1) acts as a death-inducing factor in response to interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β. It also induces autophagy, proliferation, and immune response to inflammatory signals. DAPK1 promotes the growth of p53-mutant cancers, including pancreatic and ovarian cancers. Therefore, downregulation of DAPK1 can be a potential therapeutic strategy for treating P53 mutant cancers. Overexpression of DAPK1 protein has been observed in Alzheimer′s disease (AD) patients.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 160 kDa
species reactivity mouse, human
浓度 ~1 mg/mL
technique(s) ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI登记号 P53355
UniProt登记号 P53355
运输 wet ice
储存温度 ?20℃
Gene Information human ... DAPK1(1612)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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