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位置: 首页> 品牌> Sigma-Aldrich> Anti-Caveolin-1 antibody produced in rabbit

Anti-Caveolin-1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C4490
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
6018.52 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Caveolin-1 antibody produced in rabbit
Anti-VIP21
Anti-Caveolin-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Caveolin, a 20-24 kDa integral transmembrane protein, has been identified as a principal component of caveolae membranes. Caveolin (also termed VIP21) exists in several isoforms termed caveolin-1, caveolin-2 and caveolin-3. Caveolin-1 (CAV1) (20- 22 kDa) can exist as two isoforms, caveolin-1α and -1β due to alternative splicing of the mRNA. Caveolin-1 and -2 have similar tissue distribution.

特异性

The sequence is highly conserved in many species, e.g., identical in rat, mouse, bovine, and dog caveolin-1. The sequence is not found in caveolin-2 or caveolin-3.

免疫原

synthetic peptide corresponding to a region at the N-terminus of human caveolin-1 (amino acids 2-20).

应用

Anti-Caveolin-1 antibody produced in rabbit has been used in:

  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

生化/生理作用

Caveolin can simultaneously recognize GPI-linked proteins and interact directly with a number of caveolae associated downstream signaling molecules, such as H-Ras, hetero-trimeric G-proteins, annexin-II, epidermal growth factor receptor (EGFR), protein kinase C, src-family tyrosine kinases and nitric oxide synthase (NOS) isoforms. Caveolin-1 participates in angiogenesis and is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism by controlling the expression of glucose transporters.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01633097
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 22 kDa
species reactivity rat, human, mouse
technique(s) indirect immunofluorescence: 4-8 μg/mL using HUVEC cell line
indirect immunofluorescence: suitable
western blot: 1-2 μg/mL using whole cell extract of the human endothelial ECV304 cell line and the mouse fibroblast NIH3T3 cell line
UniProt登记号 Q03135
运输 dry ice
储存温度 ?20℃
Gene Information human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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