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Anti-BACH1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
B1310
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
4731.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-BACH1 antibody produced in rabbit
Anti-BRCA1-associated C-terminal helicase 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

BTB Domain And CNC Homolog 1 (BACH1) is expressed in numerous tissues. The protein includes a nuclear localization signal in its helical domain.

免疫原

synthetic peptide corresponding to amino acid residues 1233-1249 of human BACH1 with N-terminal added cysteine, conjugated to KLH.

应用

Anti-BACH1 antibody produced in rabbit has been used in:

  • immunoblotting
  • immunohistochemistry
  • western blotting


Polyclonal anti-BACH1 antibody produced in rabbit is suitable for immunoprecipitation at a concentration of 5-10 μg by using RIPA extract (0.5 mg) of human HeLa cells and for indirect immunofluorescence at 10-20 μg/mL using human MCF-7 cells. The product is also suitable for western blot analysis at a working concentration of 0.5-1.0 μg/mL by using whole extracts of MCF-7 human breast carcinoma cells. Further, anti-BACH1 antibody has shown suitability for microarray analysis.

包装

200 μL in glass bottle

生化/生理作用

BACH1 interacts directly with the C-terminal BCRT repeats in Breast cancer type1 protein (BRCA1), a tumor suppressor nuclear phosphoprotein that facilitates the repair of double-stranded DNA breaks.Bach1 also functions as transcription repressor in transfection assays using fibroblast cells and as a transcriptional activator and repressor, respectively, in cultured erythroid cells. Additionally, it is also involved in the coordination of transcription activation and repression by Maf family members such as MafK. Bach1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) inhibits oxidative stress-inducible genes and is a negative regulator of oxidative stress-induced cellular senescence.
BTB Domain And CNC Homolog 1 (BACH1) interaction between breast cancer type 1 (BRCA1)in vivoappears to be dependent on phosphorylation of Ser990 in the latter during the G2/M phase of the cell cycle. BACH1 mutations were found in patients with early-onset breast cancer. It displays a punctate nuclear staining pattern similar to that observed for BRCA1.

目标描述

BACH1, BRCA1 interacting protein C-terminal helicase 1, encodes a protein that is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand br

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD06201924
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~150 kDa
species reactivity human
technique(s) immunoprecipitation (IP): 5-10 μg using RIPA extract (0.5 mg) of human HeLa cells
indirect immunofluorescence: 10-20 μg/mL using human MCF-7 cells
microarray: suitable
western blot: 0.5-1.0 μg/mL using whole extracts of MCF-7 human breast carcinoma cells
UniProt登记号 Q9BX63
运输 dry ice
储存温度 ?20℃
Gene Information human ... BRIP1(83990)
mouse ... Brip1(237911)
rat ... Brip1(360588)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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