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Anti-EGF Receptor antibody, Mouse monoclonal antibody produced in mouse

品牌
Sigma-Aldrich
货号
E2156
规格纯度
clone 225, purified from hybridoma cell culture
价格
4574.61 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-EGF Receptor antibody, Mouse monoclonal antibody produced in mouse
Anti-EGFR
Anti-Epidermal Growth Factor Receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-EGFR (mouse IgG1 isotype) is derived from the hybridoma 225 produced by the fusion of mouse myeloma cells (NS-1-503 cells) and splenocytes from BALB/c mice immunized with partially purified EGF receptors from A-431 cells. The receptor for epidermal growth factor (EGF) is an integral cell membrane glycoprotein of 170 kDa, which spans the membranes of a wide range of normal and malignant epithelial cells. The EGF receptor has an intracellular domain that exhibits tyrosine kinase activity.

免疫原

partially purified EGF receptors from human A-431 cells.

应用

Monoclonal Anti-EGF Receptor antibody has been used in antibody-nanoparticle conjugation.
Monoclonal Anti-EGF Receptor antibody is suitable for use in immunoprecipitation (4-8 μg using cell lysate of A431 cells).

生化/生理作用

EGFR is a tyrosine kinase receptor that regulates cellular several functions such as growth, blood vessel formation, metastasis and invasion. Alterations in EGFR expression have been associated with a wide range of cancers. Thus, drugs that target EGFR signaling have important therapeutic applications in cancer .
EGFR (epidermal growth factor receptors) protein tyrosine kinase is activated when EGF binds the extracellular binding domain. The first detectable response is the autophosphorylation of the C-terminal tyrosine followed by phosphorylation of other endogenous substrates.

外形

0.2 μm filtered solution in 0.01 M phosphate buffered saline, pH 7.4.

法律信息

This product is forin vitroresearch use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes, contact The Regents of the University of California.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00162282
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 225, monoclonal
形式 buffered aqueous solution
species reactivity human
浓度 ~1.5 mg/mL
technique(s) immunoprecipitation (IP): 4-8 μg using cell lysate of A431 cells
同位素/亚型 IgG1
UniProt登记号 P00533
application(s) research pathology
运输 dry ice
储存温度 ?20℃
Gene Information human ... EGFR(1956)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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