Anti-WSTF (N-Terminal) antibody produced in rabbit

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一般描述

The gene encoding Williams syndrome transcription factor (WSTF)/bromodomain adjacent to zinc finger domain 1B (BAZ1B), contains 20 exons extended over a length of 80kb on genomic DNA. The gene is localized on human chromosome 7q11.23. The encoded protein is composed of 1425 amino acids and is widely expressed in both adult and fetal tissues. WSTF contains one PHD-type zinc finger motif and a bromo domain.

免疫原

synthetic peptide corresponding to amino acids 2-20 of human WSTF, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, mouse, and rat.

应用

Anti-WSTF (N-Terminal) antibody produced in rabbit has been used in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).

生化/生理作用

Williams syndrome transcription factor (WSTF) acts as a key component of WICH (WSTF-ISWI chromatin remodeling complex) and the WINAC (WSTF including the nucleosome assembly complex). WICH and WINAC complexes plays a vital role in replication of heterochromatin and vitamin D-mediated transcription and replication, respectively. In addition, WSTF is also involved in neurodevelopment. Hemizygous deletion of the gene leads to a neurodevelopmental disorder, Williams syndrome (WS).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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