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Anti-TNF Receptor II, antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4502989
规格纯度
affinity isolated antibody
价格
6363.8 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-TNF Receptor II, antibody produced in rabbit
p75TNFR
p75
CD120b
p75 TNF receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tumor necrosis factor receptor 2 (TNFR2) gene with ten exons and nine introns, spanning approximately 43kbp is mapped to human chromosome 1p36.3-p36.2. TNFR2 is a member of TNF receptor superfamily, and it is expressed highly on cells of hematopoietic lineage. TNFR2, also known as CD120b or p75, TNF receptor is a 75-kDa type I transmembrane protein, characterized with cysteine-rich extracellular regions with three to six disulfide-linked domains required for ligand binding.

免疫原

The antiserum was produced against synthesized peptide derived from human TNF Receptor II.

Immunogen Range:376-425

应用

Anti-TNF Receptor 2 antibody has been used to study the effect of TNF signalling on CPF-and CPF+CM (pesticides)-induced toxicity or apoptosis in SH-SY5Y cells.

生化/生理作用

Tumor necrosis factor receptor 2 (TNFR2) plays a vital role in inducing signals for various cellular process, including proliferation of thymocytes and peripheral T cells, T cell secretion of granulocyte-macrophage colony-stimulating factor, inhibition of early hematopoiesis and the inactivation and clearance of TNF by the kidney. Mutation in the gene leads to hematopoietic cell malignancies, neuroblastoma, glioma and cervical and ovarian carcinoma. TRAF2 interacts with TNFR2 and activates NF-κB (NF-κB) pathway. TNFR2, which lack death domains modulates the effect of other death receptor TNFR1, which induces T cell death. TNFR2 plays an essential role in TNFα–induced leukocyte-endothelial interaction. TNFR2 is considered as a potential therapeutic alternative, as it has capacity to nullify the common side effects associated with drugs targeting TNF-α or p55.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 48 kDa
species reactivity human, mouse, rat
浓度 ~1 mg/mL
technique(s) ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号 P20333
UniProt登记号 P20333
运输 wet ice
储存温度 ?20℃
Gene Information human ... TNFRSF1B(7133)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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