半岛bd体育手机客户端 说明

一般描述

STIM (stromal interaction molecule) proteins are conserved single-pass transmembrane protein. The three STIM proteins, STIM1, STIM2 and D-Stim, are ubiquitously expressed proteins composed of a single SAM (sterile α-motif) domain and an unpaired EF hand within the highly conserved extracellular region and coiled-coil domains that are conserved in structure and position within the cytoplasmic region. Significant divergence between these proteins was found only at the extreme C-termini. STIM proteins are modified by phosphorylation and N-linked glycosylation.

免疫原

synthetic peptide corresponding to amino acids 812-833 of human STIM2, conjugated to KLH. The corresponding sequence is identical in rat and mouse.

应用

Anti-STIM2 antibody produced in rabbit has been used in western blotting.

生化/生理作用

STIM (stromal interaction molecule) required for the regulation of store-operated Ca²⁺influx. Store-operated calcium entry is mediated by Ca²⁺release-activated Ca²⁺(CRAC) channels, following Ca²⁺depletion from the endoplasmic reticulum (ER) stores. This process is crucial for gene transcription, proliferation and cytokine release. STIM2 is an inhibitor of STIM1-mediated store-operated Ca²⁺entry. STIM2 co-localizes with STIM1 in punctae upon store depletion, and coprecipitates with STIM1 from cell lysates, suggesting that they may play a coordinated role in controlling Ca²⁺entry.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen ~100 kDa
species reactivity	human, rat, mouse
浓度	~1.0 mg/mL
technique(s)	western blot: 0.1-0.2 μg/mL using whole extract of mouse brain western blot: 0.5-1.0 μg/mL using rat brain western blot: 0.5-1.0 μg/mL using whole extracts of human U87 cells
UniProt登记号	Q9P246
运输	dry ice
储存温度	?20℃
Gene Information	human ... STIM2(57620) mouse ... Stim2(116873) rat ... Stim2(117087)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)