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位置: 首页> 品牌> Sigma-Aldrich> Rabbit anti-BRD4 Antibody, Affinity Purified

Rabbit anti-BRD4 Antibody, Affinity Purified

品牌
Sigma-Aldrich
货号
PLA0227
规格纯度
Powered by Bethyl Laboratories, Inc.
价格
12472.4 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Rabbit anti-BRD4 Antibody, Affinity Purified
bromodomain-containing 4
Protein HUNK1
HUNKI
CAP
chromosome-associated protein
HUNK1
MCAP
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Bromodomain-containing protein 4 (BRD4) belongs to the bromodomain and extra-terminal (BET) family. The protein has two bromodomains (BD1 and BD2) connected by a long interdomain linker.

免疫原

The epitope recognized by PLA0227 maps to a region between residue 1312 and 1362 of human bromodomain-containing protein 4 using the numbering given in entry NP_490597.1 (GeneID 23476).

生化/生理作用

Bromodomain-containing protein 4 (BRD4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease. This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis. BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II.

外形

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

其他说明

Bromodomain-containing protein 4 (BRD4) contains 2 bromo-domains. Bromo-domains are found in chromatin-associating proteins and can interact specifically with acetylated lysine. BRD4 is described as a chromatin adaptor and has been shown to bind acetylated chromatin. It was originally identified as MCAP (mitotic chromosome associated protein) due to its association with mitotic chromosomes. BRD4 also associates with several transcription complexes such as the Mediator complexes and P-TEFb complexes and is considered to function as a transcriptional co-factor.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity purified immunoglobulin
antibody product type primary antibodies
等级 Powered by Bethyl Laboratories, Inc.
species reactivity mouse, human
浓度 1 mg/mL
technique(s) immunohistochemistry: 1:1,000-1:5,000
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000-1:10,000
登记号 NP_490597.1
UniProt登记号 O60885
运输 wet ice
储存温度 2-8℃
Gene Information rabbit ... BRD4(23476)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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