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Anti-TAU antibody, Rabbit monoclonal

品牌
Sigma-Aldrich
货号
SAB5500182
规格纯度
recombinant, expressed in proprietary host, clone SP70, affinity isolated antibody
价格
4661.96 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-TAU antibody, Rabbit monoclonal
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tau is a neuronal microtubule associated protein found predominantly on axons. The function of rau is to promote tubulin polymerization and stabilize microtubules, but it also serves to link certain signaling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer′s disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate tau. Alternate splicing of tau mRNA and differential phosphorylation contributes to the heterogeneity of Tau.

免疫原

Synthetic peptide corresponding to N-terminus of human tau protein.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
重组 expressed in proprietary host
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 SP70, monoclonal
species reactivity human (tested)
technique(s) flow cytometry: 1:100
immunohistochemistry: 1:100
同位素/亚型 IgG
UniProt登记号 P10636
运输 wet ice
储存温度 2-8℃
Gene Information human ... MAPT(4137)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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