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Anti-SIRT1 antibody produced in rabbit

Anti-SIRT1 兔抗

品牌
Sigma-Aldrich
货号
S5447
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
5605 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-SIRT1 antibody produced in rabbit
Anti-SIR2α
Anti-SIR2
Anti- S. cerevisiae, HOMOLOG-LIKE 1
Anti-SIR2L1
Anti-Sirtuin 1
Anti-SIRT1 兔抗
Anti-SIR2-α
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Anti-SIRT1 recognizes human SIRT1. Sirtuin 1 (SIRT1) is encoded by the gene mapped to human chromosome 10q21.3. The encoded protein belongs to the silent information regulator (SIR) family and is a class of HDAC (histone deacetylase). SIRT1 is expressed in various tissues including brain, liver, pancreas, adipose tissue, and skeletal muscle. SIRT1 is also known as the longevity gene.

免疫原

synthetic peptide corresponding to amino acids 580-593 of human SIRT1, conjugated to KLH via an N-terminal cysteine residue. The corresponding sequence differs by three amino acids in rat and mouse Sirt1.

应用

Anti-SIRT1 antibody produced in rabbit has been used in immunohistochemistry.

生化/生理作用

Sirtuin 1 (SIRT1) functions as a regulator of various metabolic pathways, and influences the pathophysiology of several metabolic diseases. It is a regulator of protein deacetylation, and is a candidate therapeutic target in non-alcoholic fatty liver disease (NAFLD), amyotrophic lateral sclerosis (ALS), kidney disease, and pulmonary disease. It also participates in tumorigenesis, and whether it functions as an oncogene or as a tumor suppressor depends upon the tumor type. In pancreatic ductal adenocarcinoma (PDAC), its elevated expression is linked with poor prognosis, and in non-small-cell lung cancer (NSCLC), it suppresses the expression of tumor suppressor p27. The encoded protein inhibits the terminal differentiation in dividing myocytes by binding to the myoD cofactor, pCAF. It is also thought to function as a suppressor of cardiovascular disorders, such as myocardial infarction, or neurodegenerative diseases, such as Alzheimer′s disease (AD) or Parkinson′s disorder (PD).

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frostfree” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

其他说明

In order to obtain the best results using various techniques and preparations, we recommend determining the optimal working dilutions by titration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD08705602
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~120 kDa
species reactivity human
浓度 ~1.0 mg/mL
technique(s) immunoprecipitation (IP): 5-10 μg using extracts of Jurkat cells
western blot: 2.5-5 μg/mL using whole extracts of Jurkat cells
UniProt登记号 Q96EB6
运输 dry ice
储存温度 ?20℃
Gene Information human ... SIRT1(23411)
mouse ... Sirt1(93759)
rat ... Sirt1(309757)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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